TTMFN: Two-stream Transformer-based Multimodal Fusion Network for Survival Prediction

Survival prediction plays a crucial role in assisting clinicians with the development of cancer treatment protocols. Recent evidence shows that multimodal data can help in the diagnosis of cancer disease and improve survival prediction. Currently, deep learning-based approaches have experienced increasing success in survival prediction by integrating pathological images and gene expression data. However, most existing approaches overlook the intra-modality latent information and the complex inter-modality correlations. Furthermore, existing modalities do not fully exploit the immense representational capabilities of neural networks for feature aggregation and disregard the importance of relationships between features. Therefore, it is highly recommended to address these issues in order to enhance the prediction performance by proposing a novel deep learning-based method. We propose a novel framework named Two-stream Transformer-based Multimodal Fusion Network for survival prediction (TTMFN), which integrates pathological images and gene expression data. In TTMFN, we present a two-stream multimodal co-attention transformer module to take full advantage of the complex relationships between different modalities and the potential connections within the modalities. Additionally, we develop a multi-head attention pooling approach to effectively aggregate the feature representations of the two modalities. The experiment results on four datasets from The Cancer Genome Atlas demonstrate that TTMFN can achieve the best performance or competitive results compared to the state-of-the-art methods in predicting the overall survival of patients

Integration in the Heterogeneous Wireless Sensor Networks Based on Network Layer

In the next generation wireless sensor networks system, various wireless technologies and wired networks in together, in order to meet the various needs of users. Our focus in this paper is to introduce a few design goals, different wireless/wired networks complement each other, thus help users to access the best network in accordance with the current business. Each network is different with each other in the network structure, application protocol and user demand, therefore need a unified public architecture to connect multiple access network. This paper surveys the novel approach of using IP technology recognized as the next generation of integration means of wireless sensor networks. This paper also presents using all-IP network architecture to support the heterogeneous access of the next generation wireless sensor networks, to support the integration and interoperability between heterogeneous wireless sensor networks, and to complete wireless mobile terminal roaming in a heterogeneous environment

Research on deep hole segmented charge cut blasting of rock roadway based on numerical simulation

With the increase of the depth of the blast hole, the rock clamping effect at the bottom of the blast hole is enhanced, resulting in low rock breaking efficiency and blast hole utilization. The past continuous charging method can not solve the above problems. On this basis, this paper studies the rock roadway deep hole segmented charging cut blasting technology to improve the cut blasting efficiency. Using the smooth particle hydrodynamics-finite element method (SPH-FEM), a single-hole cut blasting model with different segmented charge structures was established, and the blasting speed of rock particles in the rock, the number of rock blasting and the characteristics of blasting cavity were analyzed in the blasting process under different models. The results show that different charge structures affect the damage range of the rock near the blast hole, and the damage area of the traditional continuous charge structure in the direction of the blast hole is larger than that of the segmented charge structure. In addition, the continuous charge structure makes the energy distribution of the explosive uneven because the explosive is concentrated at the bottom of the blast hole, resulting in poor blasting effect. The segmented charge structure can increase the number of rock fragments and optimize the blasting cavity, and the rock particles accelerate twice in the process of flying. The large or small proportion of the first segment charge obviously causes the unreasonable use of explosive energy and the poor effect of blasting cavity. Under the conditions of blast hole length, rock parameters and explosive performance set in the simulation, when the first stage charge ratio is 0.4, deep-hole rock tunnel excavation and blasting can make full use of explosive energy to achieve better cut blasting effect. The optimal subsection ratio obtained by numerical simulation was applied to the blasting construction of roadway excavation, and the delay initiation of two explosives in the cut hole was realized by using digital electronic detonator. The field test results show that the segmented charging can create good blasting effect and improve the utilization rate of blast holes in deep hole cut blasting

Journal of Basic & Clinical Medicine http://www.sspublications.org/index.php/JBCM/index Evaluation of Tumor Cell Response to Hyperthermia with Bioluminescent Imaging

Abstract Background: Hyperthermia is used in combination with radiotherapy and/or chemotherapy in the treatment of various types of cancer. Currently, the tumor cell response to hyperthermia is determined largely based on the size reduction of tumor mass, which is insensitive. Methods: We tested the feasibility of bioluminescent imaging (BLI) in evaluation of the tumor cell response to hyperthermia by exposing luciferase-expressing MDA-MB-231-luc human breast cancer cells to high temperature (43 o C) for 10 minutes to 2 hours. The tumor cells were the imaged and the light signal generated by the tumor cells was quantified with BLI. To validate its usefulness, the light signal intensity was comparatively analyzed with the tumor cell clonogenicity and cell viability, which were measured with classic clonogenic and MTT assays. Results: The light signal intensity determined by BLI was closely correlated with the absolute number of viable cells as well as the cell viability measured with the traditional MTT assay under normal culture condition. Relative to the clonogenicity of tumor cells after exposure to hyperthermia, however, BLI underestimated, while MTT assay overestimated the cell viability. Difference in the interpretation of tumor cell clonogenic ability following hyperthermia with BLI, MTT dye, and clonogenic assay may be due to the different mechanisms of the three measurements as well as the fact that hyperthermia can induce cell damage at levels of both transient and permanent. Conclusions: BLI is sensitive, convenient, and potentially valuable in the evaluation and monitoring of tumor cell response to treatments including hyperthermia

Full Field Strain Analysis of Blasting Under High Stress Condition Based on Digital Image Correlation Method

The depth of mineral resources like coal continuously increases due to the exhaustion of shallow resources, and the characteristic of high ground stress in deep ground inevitably affects fracture of rock blasting. Combining with high-speed photography technology, the digital image correlation method (DIC) is introduced into experimental study on explosive mechanics. And strain evolution process of blasting under high stress condition is obtained by using the model experiment method. The preliminary results show that high stress condition has no obvious effects on the propagation law of blasting stress wave or its stress peak in the medium. In addition, it is found that medium in the “elastic vibration area” by conventional blast zoning is not always “elastic,” and on this basis, the concepts of “plastic area” and “quasielastic area” are put forward. The high stress condition does not influence partition range of above “plastic area” or “quasielastic area,” but in the “plastic area,” the high stress condition decreases both plastic strain value and its decay rate of relevant gauging points

Strength and Cost Analysis of New Steel Sets as Roadway Support Project in Coal Mines

Roadway support in swelling soft rocks in coal mines has become a critical challenge in recent years. For deformation control in swelling soft rocks, high strength sets are preferred in sites. But high strength always means high costs. Therefore, higher strength sets with not too much cost will be more welcomed in situ. Based on this, three new sets, including a floor beam set, a roof + floor beams set, and a roof + floor beams + braces set, have been developed in the present research. Strength comparisons and costs comparisons have been conducted in this research. Results illustrate that compared with the original set, in the floor beam set, the relative strength of bottom corners reaches 2.964, while the relative cost reaches 1.294; compared with the original set, in the roof + floor beams set, the relative strength of the top arch reaches 2.345, while the relative strength of bottom corners reaches 2.964, and the relative cost reaches 1.568; and compared with the original set, in the roof + floor beams + braces set, the relative strength of the top arch reaches 2.635, and the relative strength of bottom corners reaches 5.905, but the relative cost reaches 1.930. Floor beam set and roof + floor beams set illustrate higher strength and not too higher costs than the original set. Although the roof + floor beams + braces set exhibit much higher strength, they also demonstrate much higher costs than the original set. These new sets can be chosen according to different geological conditions in situ

Adaptive Hierarchical Handoff Optimization Scheme for Heterogeneous Wireless Sensor Networks

Abstract: This paper proposes a Mobile IP Handoff optimization scheme for heterogeneous wireless sensor networks. In the scheme, a complete solution is provided; and handoff can be effectively controlled, the network business environment can be real-time detected; the target network, the handoff type and time can be accurately judged. In addition, the handoff performance of mobile IP will be largely improved. From the theoretical and simulative perspectives, the paper analyzes the performance parameters, including the mobility handoff cost, the mobility handoff delay time and packet loss rate, and the analytical results show that the performance of the scheme is better than other schemes. Copyright © 2013 IFSA